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In keeping with our previous observation that the trafficking effects of biased GLP-1R agonists tend to exert a more pronounced effect on glucose regulation than on food intake (Jones et al., 2018b), anorectic effects of -phe1 and -asp3 peptides were similar (Figure 6J), although there was a non-significant trend towards reduced efficacy for both -phe1 compounds at early timepoints which was reversed at 8 hours
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