By 2014, the overall prevalence of hyperuricemia in mainland China had reached 13.3%, 54 and this gradually increased to 17.7% in 2017
Research in earlier phases or small trials include evaluation of GLP-1s for indications such as cystic fibrosis-related diabetes, polycystic ovarian syndrome (PCOS), chronic obstructive pulmonary disease (COPD), Prader-Willi syndrome (PWS), asthma, substance or alcohol use disorder, and as add-on to insulin for type 1 diabetes
While obesity is a primary driver of osteoarthritis and the need for joint arthroplasty, it also contributes to increased perioperative morbidity, higher infection rates, longer hospital stays, and worse long-term functional outcomes
10.1038/s41388-020-01622-3 Oncogene 131 ZhangZ.WuY.YuanS.ZhangP.ZhangJ.LiH.et al (2018)
The molecule incorporates a C20 diacid fatty acid side chain, slightly longer than the C18 side chain used in semaglutide