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Conversely, TMAO can release inflammatory factors (caspase-1, IL-1 ) (49) in a dose-and time-dependent manner by activating the reactive oxygen species (ROS)thioredoxin-interacting protein (TXNIP) NLRP3 signaling pathway (50) and inhibiting sirtun3 (SIRT3) superoxide dismutase2 (SOD2)mitochondrial ROS signaling pathway (51), thereby causing endothelial cell injury and aggravating the formation and development of atherosclerosis

Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections

It has been confirmed that many oxidative stress-related proteins, namely, paraoxonase-1, high density lipoproteins, SOD, and GPx show blood concentration changes in correlation with the endometriosis diagnosis

EM: Formal analysis, Writing review & editing

This is especially helpful if you work out several times per week on back-to-back days