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LA is a unique antioxidant that is not only effective in affording protection against oxidative stress but also plays an essential role in the metabolic processes of all living organisms 36

To understand the non-monotone behavior of GSH, it is crucial to consider that there are two incoming fluxes to GSH, GS and GR, and two outgoing fluxes, GPX and a large flux out into the blood [Figure 2B]

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However, the larger ACT trial (n=2,308) did not confirm this benefit (ACT Investigators, Circulation, 2011) [68]

Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality