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doi: 10.1124/jpet.111.182220
The idea that sermorelin needs to be cycled is not just outdated
It also inhibits matrix metalloproteinases (MMPs), enzymes that degrade ECM, preserving skin structure
As with most investigational hormones, some research models report effects such as nausea-like responses or altered feeding desire, which typically decrease as studies progress
The duration is still short enough that pulsatile GH release is preserved rather than continuous, which is one of the mechanistic reasons Tesamorelin is studied as a more physiologically-aligned alternative to recombinant human growth hormone in research models
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