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Phase II metabolism, also known as conjugation, typically involves the covalent attachment of endogenous moleculessuch as glucuronic acid, sulfate, or methyl groupsto nucleophilic functional groups on the substrate, including hydroxyl, carboxyl, or amino groups

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5 The fact that this effect was observed at nanomolar concentrations is pharmacologically noteworthy: it suggests receptor-level affinity rather than non-specific stimulatory effects