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The researchers noted that compared with the control group, the epithalamin-treated patients exhibited [10]: Decelerated aging of the cardiovascular system Decreased rate of cardiovascular mortality and cardiovascular failure (-50%) Less age-associated impairment of physical endurance Normalized circadian rhythm for melatonin production Normalized circadian rhythm for lipid (fats) and carbohydrate metabolism Lower rate of mortality (-28%) The follow-up study on long-term epithalamin treatment represents strong evidence of eptithalons favorable safety profile and relative absence of notable epithalon side effects

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F)

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Notably, aging-related AE1 protein conformational changes result in the appearance of a senescent-specific antigen recognized by autologous antibodies [75]