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Male and female mice underwent monthly intraperitoneal (i.p.) injection of either saline vehicle (PBS) or APAP (300 mg/kK body weight, Sigma-Aldrich (St

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IGF-1 Receptor Binding Characteristics Radioligand binding assays reveal IGF-1 LR3 maintains nanomolar affinity for the IGF-1 receptor while displaying reduced affinity for insulin receptors