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While well described in mice, key cells and culprits in human disease are not as clear
Known adverse reactions: Mild gastrointestinal symptoms (transient nausea, vomiting, abdominal cramps, and diarrhea) have been reported
Kyn/Trp values above the control median were observed among 83% of patients and 80% of asymptomatic carriers (Table 2) compared to the median of healthy controls
Dose, delivery, and concentration are fundamentally different
Cells and Cell culture Human Saos-2 osteosarcoma cells are p53 null
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