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The cardiovascular community, expecting the usual incremental class effect, instead got the SELECT trial, a 20% reduction in major adverse cardiovascular events in patients with overweight or obesity and established cardiovascular disease, in patients without diabetes

[1] [2] [3] [4] In support of energy metabolism, carnitine transports long-chain fatty acids from the cytosol into mitochondria to be oxidized for free energy production, and also participates in removing products of metabolism from cells

8 mg/3 mL pen: delivers 2 mg per injection, allowing for four doses

However, its potential in aiding weight loss was soon recognized, leading to its approval for this purpose under the brand name Wegovy

Ex4 is represented as orange ribbon (backbone) and sticks (side chains), and GLP-1R is represented as white ribbon