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This review was registered in Open Science Framework Systematic Review Registration: 1 Introduction The International Diabetes Federation (IDF) Diabetes Atlas (2025) indicates that 11.1% (or 1 in 9) of the population aged 20-79 is estimated to have diabetes, and more than 40% of that number does not have a diagnosis

Maximum Weight Loss Potential (Future) Amycretin Phase 1b/2a showed up to 24.3% weight loss at 36 weeks with no plateau, suggesting even greater loss with longer treatment

The first involved GLP-1 (7-37) synthesized by Mojsov, which was overseen by David Nathan, a physician and director of the Diabetes Clinic at MGH

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Both medications belong to a class called GLP-1 receptor agonists, which mimic a natural hormone in your body that regulates hunger and blood sugar