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Severe liver or kidney disease impairs glutathione metabolism and clearance

Science Advances , 11 (4), eadr8243

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The majority (90-95 %) of glutathione exist in reduced form (GSH) in healthy cells

Health and lifestyle information included smoking status (non-smoker vs current smoker), alcohol consumption as units per week, physical activity assessed using the International Physical Activity Questionnaire (IPAQ, expressed in Metabolic Equivalent Total (MET) minutes per week [46], and body mass index (BMI) measured during physical examination