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An overdose may increase the risk of serious side effects, including seizures, rapid heart rate, very high blood pressure, or severe nausea and vomiting
In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]
to obtain a zero point, a similar procedure is carried out immediately after the introduction of tert-butyl hydroperoxide
PerakAMBaker-SmithCHaymanLLKhouryMPetersonALWareALet al
That matters in chronic conditions, where treatment can last for months or even years
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