Targeting the NLRP3 inflammasome, a sensor of deleterious endogenous and exogenous stimuli, is a promising therapeutic strategy for mitigating pro-inflammatory signaling and CVD progression, particularly atherosclerosis
This work established the broader significance of NNMT in methylation-dependent cellular processes and provided context for the development of selective inhibitors [3]
However, concerns about polymer degradation, toxicity, and inconsistent BBB penetration limit their clinical application, despite some encouraging preclinical data [100, 155]
Some peptides may be accessed through compounding pharmacies on prescription, but this has tightened in recent years
Although not the primary focus, it could be an added benefit