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The therapeutic window is narrow, the degradation pathways are enzymatic and irreversible, and the difference between a successful study and a null result often comes down to whether the investigator understood that plasma half-life and biological activity duration are not the same measurement

tb in individuals with T2DM, we first evaluated the levels of GSH, MDA, and various cytokines in their plasma, RBCs, and PBMCs before and after supplementation with L-GSH or placebo

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