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Oxidative stress in arterial hypertension: role of NAD(P)H oxidase

This revelation reveals exciting possibilities in the realm of drug discovery, as GST inhibitors and its prodrugs offer a feasible strategy in designing anticancer drugs with the primary purpose of reversing tumor resistance

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The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis

Gene expression signatures of C1-27 and GSTO1 knockdown To identify pathways regulated by GSTO1 and to understand the mechanism of its antiproliferative effects, we used the nascent RNA Bru-seq method 27 to profile gene expression changes that occur in response to GSTO1 knockdown and inhibition