Chemical oxidants can rapidly decrease intracellular GSH, but are easy to produce toxic side effects such as hemolysis and nephrotoxicity [6,7,8,9]
The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]
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DOI Park JR, Lee H, Kim SI, Yang SR
Disease Prevention Cardiovascular disease Interest in garlic and its potential to prevent cardiovascular disease began with observations that people living near the Mediterranean basin had lower mortality from cardiovascular disease (88)