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The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD
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Annu Rev Public Health
When combined, they may operate synergistically, offering a model for studying both immediate and longer-term regulation of GH activity
GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation
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