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It is noteworthy that long-term HFD consumption may differentially regulate NF-B activity in hepatocytes (inhibition) and Kupffer cells (activation by lipopolysaccharide)

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Currently, we have a poor understanding of how sea urchins can maintain this downregulated state for periods of years when other marine invertebrates, such as abalone undergo complete starvation (no kelp provided) for up to 13 months before mortality occurs 30