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The most common side effects reported in trials include: Digestive issues Nausea (the most frequently reported side effect) Vomiting Diarrhoea Constipation Stomach pain or discomfort Loss of appetite Other reported effects Fatigue or tiredness Injection site reactions (redness, swelling, or irritation) Most side effects tend to be worse when starting the medication or increasing the dose, and often improve as your body adjusts

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Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase

And for some with specific risk factors, lifelong GLP-1 therapy is the best plan