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J Clin Invest (2008) 118(11):3693700.10.1172/JCI36461 28 WuTZhaoBRBoundMJChecklinHLBellonMLittleTJet alEffects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans
Finerenone induces a unique MR ligand-binding domain conformation, resulting in altered recruitment of transcriptional co-regulators compared with steroidal MRAs.97) This selective MR modulation leads to a more complete repression of pro-inflammatory and pro-fibrotic gene expression, while exerting less residual agonistic activity in epithelial tissues.97) These mechanistic differences provide a plausible biological rationale for the enhanced cardiorenal protection and improved tolerability profile observed with non-steroidal MRAs, including a lower risk of hyperkalaemiaa major barrier to MRA implementation.97, 98, 99) Two phase III trials initially evaluated finerenone in patients with CKD and type 2 diabetes
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