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"As conditions such as insulin resistance and cancer also typically increase with advancing age, it makes sense that elevated IGF levels in older age, may not be reflective of good health, as opposed to a higher IGF-1 in a younger person due to their health-promoting lifestyle behaviors." The researchers of the Aging Cell study highlight that the link between IGF-1 and health risks is U-shaped, implying that both high and low levels of IGF-1 may indicate unfavorable health outcomes

reinhardtii APK was identified as a TRX-target as well (Prez-Prez et al., 2017)

Frasch MG, Yoon BJ, Helbing DL et al (2023) Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins

J Clin Endocrinol Metab 100(11):40374047 Ferrari SM, Fallahi P, Antonelli A, Benvenga S (2017) Environmental issues in thyroid diseases

doi: 10.1016/j.neuropharm.2015.11.005 153 SadekB.SaadA.LataczG.KuderK.OlejarzA.KarczT.et al