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To address this, we performed transcription profiling using Bru-seq and identified genes involved in cellular stress response, steroid metabolism, transcription and cytoskeleton organization as significantly altered by both GSTO1 siRNA and C1-27

Oxidative Stress and Damage: A Vital Pathogenic Mechanism of CIPN It is well established that the production of reactive oxygen species (ROS) by antineoplastic agents induces apoptosis in cancer cells [14]

BSN Health, Analyses, Innov., Consult., Org., Agricul., Industry Ltd., Isparta, Trkiye, provided financial assistance for this study

Therefore, future research efforts will be necessary to clarify the mechanism of enzyme inhibition played by auranofin on GSTs

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