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One concern is that, if pre-cancerous cells are already present, very high availability of growth-supporting nutrients such as B12 could, in theory, support their growth too
The condition is more prevalent in males and presents as insidious onset pain at the proximal insertion site of the quadriceps tendon over the patella (20% of cases), pain at the inferior pole of the patella (70% of cases), or less commonly, pain at the tibial tuberosity (10%), which may increase during physical activity and digital pressure [4,5,6]
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But it could be helpful to screen people for B12 deficiency in advance and give them B12 supplements to delay or prevent the onset of depression