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Most people regain significant weight within 12 months of discontinuation, not because the drug wore off, but because the biological suppression it provided disappears
Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T et al
BMC Biochem 19:7
S2CID 17260700
In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)
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