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Given that several further dual agonists are coming closer to becoming licenced, such as mazdutide and survodutide, with many more in development [15], combining licenced dual agonists with developing mono-agonists may be a faster way to develop effective treatments achieving triple agonism
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We thus decided to start our investigation by replacing four consecutive amino acids (X 4 ) with three consecutive ureido residues (X u 3 ) based on our model, suggesting that this combination gives the best overlaps of the terminal atoms (Fig
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