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Special considerations for different populations Treatment duration recommendations vary based on patient characteristics that influence metabolic response and risk

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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1