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Make gentle diet adjustments Build balanced plates Non-starchy vegetables + quality protein + healthy fats (e.g., coconut oil or olive oil)

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Vitamin B12 injections can quickly help symptoms improve

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An alternate possibility is that cytosolic NADPH manipulation ultimately affects matrix NADPH status through metabolite shuttles, which are used to convey reducing equivalents across the mitochondrial membranes by coupling mitochondrial redox reactions with their cytosolic counterparts (for example, using the transport of citrate to couple IDH2 and IDH1) (Taylor, 2017)

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