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Relevant clinical diseases Neurodegenerative diseases Generally, neurodegenerative diseases (NDDs) exhibit multiple and common pathological effects, including defects in mitochondria, protein quality control, and the autophagic-lysosomal network, which lead to the aggregation and accumulation of misfolded proteins [173, 174]
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Actionable Insights: The foundational biomarkersincluding HbA1c, metabolic panels, and kidney function markersmove the needle on long-term healthspan
The STEP 1 trial showed average weight loss of 14.9% over 68 weeks, with around half of participants losing 15% or more of their body weight
Together, the two drugmakers dominate the market for GLP-1s
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