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243 Complement system activation recruits immune cells and disrupts the bloodretinal barrier, further promoting retinal inflammation and the progression of AMD

(not alternatives, essential use) for #PFAS used during #API manufacturing, but these derogations come with obligations

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Furthermore, H promotes the polarization of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, thereby inducing the secretion of anti-inflammatory mediators like IL-10 and TGF-, which contributes to the establishment of a positive regulatory feedback loop