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The meta-analysis by Wang and colleagues 137 included an unpublished trial (NCT00845507 145 ) that was not part of the more recent meta-analysis by Khaity and colleagues 134

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As with semaglutide and tirzepatide, the main adverse events of retatrutide were GI-related and included nausea, which was most common in the 8-mg group who started at an initial dose of 4 mg

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