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A key concept therefore, in the development of OAB and IC/PBS, is chronic sensitisation of the neuronal networks regulating bladder sensation, incorporating structural, synaptic, or intrinsic changes of peripheral or central structures that may drive subsequent changes in downstream sensory pathways (Grundy et al., 2018c)

A researcher running a 48-week protocol at 4mg weekly needs significantly less total material than one targeting 12mg maintenance

Eat protein first at every meal, before vegetables or fats, especially on days when appetite is low and you know you wont finish the plate

For many others, it falls short

Take extra care with hydration and small, frequent meals if nausea occurs