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This gradual approach allows monoamine transporter downregulation to catch up with inhibition, which is why the 'best' time is less about absorption mechanics and more about minimising side effects during dose establishment
These endpoints can differ widely in robustness
Devos et al., 2014
373 In fact, when BMSCs are exposed to exendin-4, the expression of genes related to bone development factors such as Runx and Osterix, as well as genes responsible for producing the bone matrix such as Balp and Bglap, is upregulated
Antioxid Redox Signal (2016) 24:54855
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