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Individuals with a history of medullary thyroid carcinoma or certain endocrine disorders should avoid this treatment

Centrally, GLP-1 receptor agonists act on hypothalamic appetite centers to increase satiety and reduce food intake

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That said, a real-world analysis by Prime Therapeutics and Magellan Rx looked at integrated pharmacy and medical claims data from 16 million commercially insured members and found that a whopping 68% had stopped taking their GLP-1s after just one year

To further characterize these effects, we examined pancreatic islets histologically