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Given that obesity and hypertension frequently coexist and together substantially increase cardiovascular and kidney risk, these findings support obesity treatment as an important component of blood pressure management and cardiovascular risk reduction, said lead researcher Marcel Muskiet, MD, PhD, an internist, endocrinologist, and vascular medicine specialist in the Department of Medicine at Leiden University Medical Center (LUMC) in the Netherlands

Additionally, fatty liver disease, high cholesterol, and osteoarthritis related to excess weight are recognized as conditions that can support treatment eligibility

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Patients should contact their GP or diabetes specialist nurse if they experience: Severe or persistent vomiting that prevents adequate fluid or food intake, as this increases the risk of dehydration and hypoglycaemia Severe abdominal pain , particularly if constant or radiating to the back, which could indicate pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists Sudden pain in the right upper abdomen, fever or jaundice , which may indicate gallbladder problems (cholelithiasis or cholecystitis) Blood in stools or black, tarry stools Unexplained weight loss beyond what is expected from the medication's therapeutic effect Signs of dehydration , including reduced urine output, dizziness, or confusion Persistent diarrhoea lasting more than a few days Symptoms that significantly impair quality of life or prevent adherence to the medication regimen Pancreatitis is a particular concern with semaglutide, though it remains uncommon