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When that valve weakens or opens more frequently, stomach acid irritates the esophageal lining, triggering the burning sensation you recognize as heartburn or GERD symptoms
Recently, DPP-4 inhibitors have increasingly replaced sulfonylureas as second line therapy after metformin failure and many metformin/DPP-4 inhibitor fixed dose combinations are available
CPT1A has a higher affinity for its substrate carnitine and a lower affinity for the physiological inhibitor malonyl-CoA than does the muscle isoform
