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Many age-related changes in circadian rhythms and sleep architecture, such as reduced rhythm amplitude, phase advance, and altered sleep consolidation, may reflect adaptive remodeling of the circadianhomeostatic system rather than intrinsic dysfunction (Scullin and Bliwise, 2015)

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But in this case, the Delegate decided to seek further advice by setting up an independent expert review panel to review the therapeutic value, risks and benefits to public health outcomes for these substances, as well as seeking additional advice from the Advisory Committee on Medicines Scheduling following the review