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The metformin concentration in the jejunum peaks at 500 g/g, 30300 times greater than plasma concentrations [13], highlighting the small intestine as an important site of metformin uptake

Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87