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As leses pigmentadas orais na Doena de Addison so causada pela produo aumentada do hormnio adrenocorticotrpico (ACTH) e do hormnio estimulante de melancitos (-MSH), em resposta produo reduzida do cortisol pela glndula adrenal

In this pathway, SAM is decarboxylated by SAM decarboxylase, generating decarboxylated SAM (dcSAM)

Conversely, the increased SOD activity in the cerebellum of the VPA group suggests compensatory antioxidant responses in specific regions

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