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The glucose-dependency of GLP-1s insulinotropic effect it only amplifies insulin secretion when blood glucose is elevated is a key pharmacological property that distinguishes GLP-1 from non-incretin insulin secretagogues in research models
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NICE Guideline NG12 (Suspected cancer: recognition and referral) defines criteria for urgent two-week-wait referral for upper GI cancer, including dysphagia, unexplained weight loss, and persistent symptoms in older adults these criteria apply regardless of whether symptoms arise in the context of medication use
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