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Contraindications: Not indicated for use in: Type 1 diabetes mellitus tirzepatide is not a substitute for insulin in insulin-dependent diabetes Diabetic ketoacidosis requires immediate insulin therapy, not GLP-1 receptor agonists Cautions and special considerations: Severe gastrointestinal disease , particularly severe gastroparesis, as tirzepatide may worsen symptoms due to delayed gastric emptying History of pancreatitis requires careful risk-benefit assessment and close monitoring Dehydration risk particularly important in patients with renal impairment, though tirzepatide generally requires no dose adjustment based on renal function [21] [1] Pregnancy and breastfeeding not recommended due to insufficient safety data

In clinical trials, people who took lower doses of semaglutide lost less weight than those who took higher doses

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TNBC is associated with higher histologic and nuclear grades and a poorer prognosis compared to other subtypes (103)

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