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The conservative reasoning researchers describe generally includes: Titrate one variable at a time
The absence of pharmacokinetic or pharmacodynamic interaction studies means healthcare providers must rely on theoretical considerations and the known pharmacology of each component when patients inquire about combination use
No visible effect yet
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Within 72 hours after injection of 500 to 1000 mcg of hydroxocobalamin, 16 to 66 percent of the injected dose may appear in the urine
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