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These medications effectively help drown out the food noise
Phase 2 results for a weekly injection found a mean 24.3% weight loss at 36 weeks with the 60mg dose
Because these medications are similar, the side effects are too, but the frequency can vary with dose and medication
A 2023 analysis in Obesity Surgery noted that GLP-1 therapy showed modest weight loss benefit in patients 2-5 years post-bypass, but safety required careful monitoring for malabsorption and nutrient interaction
Appropriate reasons to discuss discontinuation include achieving your weight loss goals and wanting to attempt weight maintenance without medication, experiencing intolerable side effects that don't improve with dose adjustment or supportive management, financial constraints that make continued treatment unsustainable, planning pregnancy (semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception), or developing contraindications to continued use
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