10.1152/physrev.00001.2017 27 ErpicumP.RowartP.DefraigneJ
Extreme calorie deficits accelerate muscle loss
A 2020 review by the Journal of the International Society of Sports Nutrition (JISSN) summarized over 70 studies and found that L-carnitine supplementation: Improves muscle oxygenation during exercise Reduces exercise-induced muscle damage Enhances recovery rates after intense workouts Provides mixed results for direct weight loss, although it consistently supports fat metabolism These findings help answer the question does L-carnitine work, especially when your goal is improving performance and recovery rather than relying on it as a standalone fat-loss supplement
The closest thing to an evidence-based loose skin protocol is: adequate protein, resistance training, gradual weight loss when possible, sun protection, retinoids for facial use, topical GHK-Cu as adjunct, hydration, and patience
In summary, this study demonstrates that once-weekly semaglutide treatment in patients with heart failure with preserved ejection fraction can lead to reductions in symptoms and physical limitations as well as greater weight loss as compared to placebo