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Prudence remains warranted when administering probiotics to immunocompromised individuals, including neonates, patients with centrally inserted venous catheters, postoperative patients, and those with severe comorbidities

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Several studies have evaluated curcumin to reduce muscle soreness, pain, and loss of power after exercise

Incompletely established adverse effect profile : Although Phase 2 trial data (NEJM, 2023) provides some safety information, the full adverse effect profile of retatrutide has not yet been established through the complete Phase 3 programme

For example: On type 2 diabetes Published in Frontiers in Endocrinology , a 2026 case report by Pendulum researchers describes treatment for a 52-year-old man with a medical history of hypertension and type 2 diabetes mellitus