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Repeatedly injecting into the same spot can lead to tissue changes that affect medication absorption and may cause discomfort or cosmetic concerns

To minimise gastrointestinal side effects, Mounjaro is initiated at a low dose (2.5 mg once weekly) with gradual titration every four weeks, allowing patients to develop tolerance

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Furthermore, increases in haematocrit and uric acid-lowering effects were observed, which is relevant because these biochemical alterations are closely linked statistically as mediators of clinical benefits of SGLT2i in kidney and cardiovascular outcome trials [40, 41]

Higher doses do not increase glucose excretion proportionally and increase the risk of side effects without added benefit