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The clinical drug development program was halted in 2007 after the pivotal Phase IIb trial did not show statistically significant weight loss in the primary endpoint
Instead of jumping from 2.0 mg to 2.5 mg, go to 2.25 mg for two weeks, then 2.5 mg
Once NAC is absorbed, the liver uses it to synthesize glutathione
In the Peptology range it is available under the Retagon brand
Future prospective studies should adopt a more comprehensive methodological approach, including measures of insulin resistance (eg, HOMA-IR), hypoglycemia monitoring, and validated quality-of-life questionnaires, to better reflect the full impact of GLP-1 analogue therapy on patient outcomes
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