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Staying hydrated and avoiding long gaps between meals can also prevent nausea or dizzinesscommon early side effects of GLP-1 medications
doi:10.1002/oby.24067 Sievenpiper JL, Ard J, Blher M, et al
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These observations are more broadly relevant to drug discovery at peptide GPCRs for which ligand acylation is a valid approach to improve pharmacokinetics
The development of triple agonists (e.g., GLP-1/GIP/glucagon agonists like Retatrutide) or other multi-target agents (e.g., GLP-1/amylin/GIP) represents the next frontier in drug discovery (31)
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