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Disclaimer: Retatrutide is an investigational compound
GLP-1R-expressing neurons innervating the stomach react to gastric distension and transmit signals to the hypothalamus to suppress food intake 7,21
This medication mimics the action of the GLP-1 hormone, promoting insulin production, reducing hunger, and supporting weight management efforts
The landmark Rudman study demonstrated that GH restoration in older men produced significant improvements in lean mass, fat mass, and skin thickness (9)
As hypothesized, while financial barriers were the most common reason for discontinuation at all time points, patients discontinuing due to cost were more likely to do so later in treatment, whereas those discontinuing due to side effects tended to do so earlier
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