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Considering the interconnected molecular pathways that associate vascular and muscular health, strategically targeting the musclevasculature axis through a combined regimen of CIT and leucine supplementation alongside exercise may present a synergistic strategy for the preservation of muscle metabolism, enhancement of vascular function, and prevention of sarcopenia in the context of aging

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TMAO and CVD-related diseases In addition to CVDs, TMAO promotes numerous related diseases, such as diabetes, CKD, etc., which have a burden of cardiovascular complications (133, 134)

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Safety varies by peptide type, source, dosage, and medical supervision